Enhancement of dissolution rate of racecadotril by liquisolid compact technology

The current investigation was used to improve the rate of dissolution an anti-diarrheal drug i.e., racecadotril (RT) at low pH conditions (i.e., in stomach) by reducing water secretion and electrolyte intestine liquisolid tablets. Different formulations (liquisolid) were prepared using Avicel PH 102 as a carrier. Aerosil 200 coating material sodium starch glycolate disintegrant. Polyethylene glycol non-volatile vehicle dissolve drug. FTIR, DSC, XRD studies conducted characterise Characterisation indicated that no interactions between carrier Solid state characterization had shown reduction crystallinity further supports increment solubility dissolution. optimised formulation showed significant increase 99.54±0.62% 30 min compared directly compressible tablets (38.47±0.26%). % efficiency 76.86% marketed tablet (27.56%) conventional direct compression (17.11%). Significant mean time from (6.84 min) (44.57 min), indicating faster release onset action. Formulation could enhance solubility, bioavailability racecadotril.